Books and key references

Research context for monitoring, inflammation, sleep, and PANS/PANDAS.

These references support educational framing only. RubyHealth summaries are not diagnostic claims and must be reviewed with qualified clinicians.

Head and brain educational infographic for RubyHealth key references

Why these references matter.

RubyHealth's content strategy connects several evidence areas: inflammation and autonomic function, wearable pre-symptomatic monitoring, sleep-immune crosstalk, and clinical evaluation of PANS/PANDAS.

The product goal is to help organise context for review, not to replace physician judgement.

How RubyHealth uses this research.

The content framework connects inflammation, autonomic balance, sleep architecture, smartwatch monitoring, and PANS/PANDAS clinical evaluation into a monitoring-first product strategy.

The app should help families and clinicians see patterns over time: what changed, when it changed, and which signals moved together.

Reference list

Core papers to cite in future content.

Tracey, K.J. (2002)The inflammatory reflex. Nature, 420, 853-859.Open Nature article

Mishra, T. et al. (2020)Pre-symptomatic detection of COVID-19 from smartwatch data. Nature Biomedical Engineering, 4, 1208-1220.Open Nature article

Thayer, J.F. et al. (2010)Autonomic imbalance, HRV and cardiovascular disease risk factors. International Journal of Cardiology, 141(2), 122-131.Open DOI

Irwin, M.R. & Opp, M.R. (2017)Sleep health: reciprocal regulation of sleep and innate immunity. Neuropsychopharmacology, 42(1), 129-155.Open PubMed

Swedo, S.E. et al. (2012)Modifying the PANDAS criteria to describe PANS. Pediatrics & Therapeutics, 2(2).Open article

Chang, K. et al. (2015)Clinical evaluation of youth with PANS. Journal of Child and Adolescent Psychopharmacology, 25(1), 3-13.Open article

Krueger, J.M. et al. (2008)Sleep as a fundamental property of neuronal assemblies. Nature Reviews Neuroscience, 9, 910-919.Open Nature article

Besedovsky, L. et al. (2019)The sleep-immune crosstalk in health and disease. Physiological Reviews, 99(3), 1325-1380.Open DOI

Dantzer, R. et al. (2008)From inflammation to sickness and depression. Nature Reviews Neuroscience, 9(1), 46-56.Open Nature article

Background readingGeneral PANS / PANDAS overview for non-specialist readers.Open NIMH overview