What is PANS / PANDAS?
PANS, or Pediatric Acute-onset Neuropsychiatric Syndrome, describes a clinical syndrome where children experience sudden, dramatic onset of symptoms such as obsessive-compulsive disorder, severe anxiety, emotional lability, behavioural regression, cognitive changes, or other neuropsychiatric symptoms.
PANDAS, or Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections, is generally described as a subset associated with Group A streptococcal infection. In this framework, immune activity may affect brain pathways involved in behaviour, movement, emotion, and regulation.